The vibration of automobile pipeline is caused by the vibration environment of automobile body.Continuous dynamic load will lead to local vibration failure of the pipeline system.It is very important to control vibration of pipeline system to ensure safe running of automobile.In order to solve the leakage failure of an automobile oil-cooled pipe in operation,a 3D model was established based on the pipeline system,frequency response analysis and fatigue analysis of the pipeline system were carried out by ANSYS software,and its natural frequency and cumulative damage were calculated.The results show that the fatigue life of the pipeline does not accord with the design life requirements,and the dangerous weak point shown by the simulation is close to the actual cracking and leaking failure position.The structure of the pipeline system was optimized by adjusting the thickness of the pipeline wall,increasing the fixed support points and changing the direction of the pipeline.The optimized pipeline structure continues to vibrate for 68 h without leakage failure.