In this paper, the discrete phase model (DPM) and semiempirical wear model were used to simulate the unsteady solidliquid twophase flows and wear in a centrifugal pump, to explore the solid particle movement and the wear of the pump. The liquid phase was solved by the fluid governing equations in the Euler coordinate system; the solid particle phase was treated as a discrete medium and solved by the equations of particle motion in Lagrange coordinate. The solidliquid phase coupling was performed using iterative numerical method. An IS type centrifugal pump was selected in the simulation. Water and sand particle were chosen as the continuous phase and the discrete phase, respectively. The particle volumetric ratio at the pump inlet was in the range of 0.5%-3% with the particle size of 0.05-0.2 mm. The flow characteristics of the solidliquid twophase flows, the trajectory of the particle cluster and the distribution of wear rate in the centrifugal pump were obtained by the simulation.