GH4099, a difficult material commonly used in aerospace, cannot be machined well by conventional machining, so this paper selects Short electric arc machining (SEAM) for GH4099. In order to explore the optimal combination of parameters for GH4099 SEAM, we designed orthogonal experiments to measure the material removal rate (MRR), relative electrode loss rate (RTWR) and surface quality. The optimal combination of parameters can not only broaden the processing method of GH4099 material, but also realize the efficient processing of this material.