The dynamic response is the most popular engineering analysis content, which is used to determine the structures loading dynamic with the change of time.It is difficult to have the dynamic response analyis for the box because the runtime bearing force is constantly changing and irregular. Dynamics simulation model of gearbox drive system by using ADAMS was established and dynamic force at the bearing was obtained through analysing multi-body dynamics.On this basis, bearing force was applied to the box body by using the finite element software, and the box body structure of dynamic response was solved,the experiment proved the effectiveness of the response analysis.