Based on the analysis of structural characteristic of typical complex curved surface radial flow impeller，the traditional process was improved with application of advanced technology and software platform.Based on general programming strategy of NX,the advanced fiveaxis machining center was used to process a small diameter multistage blade impeller,the machining efficiency was elevated about 384% compared with the previous. This processing technique improves the production quality and satisfies the design requirement of the parts.The method provides an enlightening instruction on the manufacturing process of similar structure parts.