In order to realize the function features of smooth centering, precise positioning, and large carrying capacity in the indexing process of the machining center disc type tool magazine, the mathematical model of the cylindrical indexing cam mechanism for the disc type tool magazine is established using the conjugate principle of the space envelope surface. The working contour data of the cylindrical indexing cam was obtained by analysis, and the cylindrical indexing cam was designed and parametrically modeled using NX three dimensional (3D) software. The virtual prototype based on NX simulation module was established to perform kinematics and dynamics simulation analysis and output relevant characteristic curves. The simulation result data shows that the design method of the cylindrical indexing cam mechanism is correct, and it has reference value in the further optimization design and manufacture of the mechanism.