The mechanical structure of an automatic edging and drilling processing unit for a flexible glass production line was introduced, and the working principle of the processing unit was explained. The pneumatic hardware was reasonably selected and the pneumatic control circuit was designed. With PLC as the core, the system hardware development and control flow design were carried out, and then an effective drilling position control method was proposed. The functions of automatic loading and unloading,automatic edging, drilling processing, and processing accuracy control of the processing unit were realized.