In the mass production of large-size locomotive bearing block parts, there are many parts with similar structure and different size. In order to shorten the processing programming time, a general process scheme was designed based on the typical features classification and characterization of bearing seat parts. VB language was used to carry out secondary development on ESPRIT software platform, the automatic programming template for different features was established, so that the automatic programming for different size parts could be completed quickly. A group of bearing parts was machined with DMG CTX1250 turning and milling complex machining center, to verify the effectiveness of the automatic programming module. This method can effectively shorten the programming time of batch parts. It provides an effective automatic programming method for intelligent machining