In order to analyze the effect law of turning parameters on machined surface roughness, machined surface topography and residual stress, orthogonal turning experiments were designed for GH4169, and 3D turning model was established by finite element simulation. The results show that the main and secondary factors affecting the surface roughness are feed rate, cutting speed, depth of cut in order; the main and secondary factors affecting the residual stress are feed rate, depth of cut, cutting speed in order; the optimal parameter combinations for surface roughness and residual stress within the experimental parameters are respectively determined to be vc=55 m/min,f=0.1 mm/r, ap=0.3 mm and vc=60 m/min, f=0.2 mm/r, ap=0.25 mm.