Abstract:A manufacturing system for microfluidic devices was designed based on glass thermoforming technology. The system could draw microglass tubes with different specifications based on flame heating and sequential control of multiple sets of motors. Through software,a simulation analysis model was established for the temperature change of the microglass tube during the heating process,the temperature distribution change of the micro glass tube during the heating process was analyzed, to provide reference for the heating time experiment of the microglass tube, and the microglass tube softening area under different heating times was explored.By changing the heating time of the preparation system, the rotation speed of the stretching motor, the width of the heating area, and the type of the microglass tube,microfluidic devices such as microneedles and microtubes with different sizes could be drawn.Experiments about heating time,drawing speed and heating width were made to explore the effect of various parameters on the morphology and size of microfluidic devices. Compared with traditional manufacturing system, the system not only has a variety of adjustable parameters, but also can realize the preparation of microfluidic devices with different sizes by replacing collets with different inner diameters, so that the drawing range is wider.