In order to improve the safety and accuracy of the positioning work of the ultra-high acceleration macro-micro motion platform,taking the flexible positioning platform,the key component of the macro-micro motion platform,as the research object,the influence of the macro-micro motion platform on the fatigue life of the flexible positioning platform under the micro-positioning condition was explored.The 3D model of the flexible positioning platform was established by SolidWorks,and the static analysis and transient dynamic analysis were carried out in ANSYS Workbench to obtain the location of the dangerous point of the flexible positioning platform and the load spectrum used for fatigue analysis.The fatigue evaluation of the platform was carried out using the Goodman curve evaluation method.The data obtained were all within the Goodman curve frame,and the evaluation results were reasonable.Finally,nCode was used to calculate the fatigue damage and fatigue life of the flexible positioning platform.It is concluded that with the increase of the driving frequency,the fatigue life of the flexible positioning platform is decreasing.The research results provide reference for the research of the ultra-precision positioning platform.