The new high-quality γ-TiAl based alloy Ti-48Al-2Cr-2Nb with low density, high specific strength and good high temperature mechanical properties has a broad application prospect in aerospace and precision micro parts manufacturing field. In order to study the micro-milling performance of the material, a four-factor and five-level orthogonal experiment was carried out by using a double-edged cemented carbide micro-milling cutter with a diameter of 0.8 mm. The effects of spindle speed, feed speed, milling depth and milling cutter spiral angle on the burr and roughness of micro-milling were studied. The results show that the spindle speed and milling depth are important factors affecting the top burr, and the influence of the milling cutter spiral angle on the groove bottom surface roughness is the most obvious. The results provide a theoretical basis for the micro-scale milling of γ-TiAl based alloy.