The multi-body dynamics of HE63 horizontal machining center was simulated and analyzed based on the Rigit Dynamic and Transient structual modules of ANSYS Workbench platform.The vibration and deformation of spindle and guide surface were analyzed using the rigid-flexible hybrid model.The results of dynamic analysis and static analysis were compared.The simulation results show that the deformation and vibration of the machine are large during the startup,acceleration and deceleration;the spindle rotation has a great influence on the vibration of the column and the headstock,and the vibration of the machine parts directly affects the machining accuracy of the machine.