Aimed at the puzzle of fault tolerance service resulted in highly heterogeneous grid itself, this paper explored a sort of design on framework of dynamic fault tolerance service faced to grid computing. In the paper, the fault tolerance requirements of grid computing was analyzed and summarized, and the definition of the relevant fault was presented based on the grid environment. The classification model of the fault was established in this paper and a kind of dynamic fault tolerance service framework was put forward in which the grid fault detection and fault management was included. The function of each component was described one by one in the grid framework, and finally, the detailed flow of fault tolerance service was presented. The elementary simulation experiment partially demonstrated the feasibility and rationality of the proposed framework. The research results show that it could provide a new reference framework for dynamic fault tolerance service faced to grid computing.