A parametric design method was presented for one level cylinder of 4M12-78/34 oxygen compressor. Pro/E software was developed secondarily with VC++ to program the parametric design software. The two-level cylinders were designed by using this method. Comparing with conventional design method, it is prove that the method has high precision, reliability and suitable for cylinder design of 4M12 other models. The cylinder design time is saved more than twice. The research provides theory basis for the parametric design of 4M12 compressor.