Cylindrical cam is a kind of widely used intermittent mechanism, cylindrical cam groove curve processing is more complicated. Using machining center with four shaft linkage function, CNC machining can simplify operation to improve accuracy and efficiency of the parts. Taking HNC-210B MD system as an example, the technical design of CNC machining was described, as well as presetting cutter operation and programming methodology. Focusing on the macro program programming method, the advantages and disadvantages of automatic programming using CAD/CAM software were introduced. It provides reference for CNC machining of cylindrical cam groove.