Three groups of pneumatic actuator and electric actuator system most commonly used in the industrial field were taken as the research object. The main cost factors of these pneumatic actuators and electric actuators were analyzed. And the assessment standards and computation model of LCCBPO (Life-cycle Costing Based on Product Owner) about the two kinds of pneumatic actuators and electric actuators were set based on LCC(life cycle cost). The LCCBPO of two kinds of the actuators mainly includes: acquisition cost, operation and maintenance cost and scrap recycling cost. The LCCBPO model was analyzed and verified through the application data of three groups of pneumatic and electric actuators in common conditions. Conclusions: (1) In the same load capacity and travel conditions, acquisition cost of pneumatic actuators is less than one of electric actuator, running maintenance cost of rod cylinder is less than one of electric actuator, and scrap recycling cost of pneumatic actuator is less than one of electric actuator. (2) In general, overall life cycle cost of pneumatic actuators is less than one of electric actuator more economical and practical in the PTP (point to point) handling conditions.