Currently, the artificial typesetting way is adopted by most of art mosaic production enterprises, which is inefficient but high error rate. In order to solve this problem, a mosaic automatic typesetting production line was designed, with the detailed introduction about design and selection of key institutions, especially focusing on the difficult issues liked automatic feeding of art mosaic, resorting to consistent material surface, discriminating and flipping the positive and negative sides and occupying large space of collection part. Finally, the automatic typesetting was achieved. On this basis, mosaic typesetting process flow and control solution were prepared.