Aiming at the grinding wheel balance device equipped with three balance blocks, according to the unbalance value of the grinding wheel, two different calculation methods of the balance blocks quantity adjustment were put forward. When the grinding wheel was taken dynamic balance for the first time or the grinding wheel had a lot of unbalance, the problem that how to calculate each target angle of the three balance blocks was solved through the balancing method of moving three balance blocks equipped. When the grinding wheel needed to take precise dynamic balance or to take dynamic balance again after a period of time, the problem that how to calculate the quantity of the balance blocks adjustment was solved through the balancing method of perturbation moving the balance block. At last it is proved by experiments that by using the two methods above during the dynamic balance of the grinding wheel, can improve the grinding wheel balancing efficiency and reduce the times of grinding machine start and stop during balancing process.