It is hard to exceed 400 km/h that the maximum economic speed of high-speed trains running on the atmosphere, so the Evacuated Tube Transportation (ETT) will be one of the ideal much faster vehicle on land. By taking high speed train set as a research object, based on Pro/E, the parameterized model of ETT system was established. Analyzing the train boundary condition in actual operation, in FLUENT software, based on the k-ε double equations turbulence model, the numerical simulation and computation were done under coupling condition which involved many fields such as the outer flow field, the aerodynamic drag field and velocity field. Furthermore, the rules of many parameters affected air-resistance and aero-lift were researched such as the atmospheric pressure in evacuated tube, travel speed, the locomotive’s geometry and train-tube dimension ratio. By using of fuzzy multi-criteria evaluation model, the main parameters of system are optimized in design, which provide the reference for the feasibility design of ETT.