This paper describes the design and performance testing method for electromagnetic proportional pressure relief valve. The valve uses proportional solenoid as a driving element so that the pressure could be real timely adjusted, which will meet the needs for different pressures required by laboratory analytical instruments. By using the spring-energized reciprocating seals in the valve to strengthen the sealing performance, the safety of the high pressure analytical instruments could be improved in laboratory. In addition, it can also constitute a closed loop control with pressure sensors and flow sensors.