By taking Vertical MillingTurning Combinational Machining Center VMT100 as a prototype, virtual simulation of actual processing was operated on the computer by numerical control (NC) machining simulation software VERICUT. Simulation of NC machining processes and considerations of Vertical MillingTurning Machining Center VMT100 based on VERICUT were introduced. The machine simulation environment of VMT100 was built in VERICUT. A tool library that the NC machining of wheel hub mold needed was built. By taking the NC milling machining of hub mold as an example, VERICUT NC machining simulation was introduced. The results show that the simulation established on VERICUT of the special simulation platform is very important to verify the NC code, and to check potential process mistakes of collisions and to calculate machining time. Moreover, it can help to improve NC programming efficiency and machining quality, and to cut down trial run and to reduce the process cost.