To enhance the machining precision and efficiency of lightweight automaticholemakingsystem for aircraft industry, end effector for generating holes must have high vibration resistance, and its mass should be as light as possible. Taking a revolution assembly of new orbitaldrillingendeffector as research object, a multiobjective optimization mathematical model of the revolution assembly was established by finite element modal analysis. In the optimization model, the first four order natural frequencies of the revolution assembly and the mass were selected as the objective functions and the geometric dimensioning of key parts were selected as the design variables. Based on response surface method and orthogonal experimental design, the second order response surface model of revolution assembly was built. The accuracy of the response model was verified by comparing predicted value resulted from response surface model and calculated value resulted from finite element model. The optimal solution of revolution assembly multiobjective optimization was obtained by solving response surface optimization model, which made the first four natural frequencies increasing 918%,543%,4126%,4917% respectively, the mass of revolution assembly decreasing 17%. 