Plunger rod and eccentric wheel of ultrahigh pressure and microflow pump are the main pressure parts,and became the main object of study design.The threedimensional (3D) model was established in Pro/E,the modal neutral file (MNF) of the critical parts was obtained through ANSYS.CoSimulation of ADAMS and ANSYS implements the main mechanical parts of the stress and displacement analysis,and shortens the product development cycle and reduces development costs.