The cutting two dimensional (2D) simulation model of cutting TC4 titanium alloys by YG8 carbide tools was built based on ABAQUS. The cutting temperature of simulation model was verified through the cutting temperature measured by the infrared camera, and the relationship between cutting speed, feed rate, cutting tool rake angle, cutting tool relief angle and cutting temperature was studied through the simulation model. The prediction model of cutting temperature was got by CCD (Central Composite Design). The research results show that: the deviations of cutting temperature between simulation model and experiment are within 10%. Within a certain range, an increase in the cutting speed and feed rate increases the cutting temperature. An increase in the rake angle decreases the cutting temperature. Along with the relief angle increasing, the change of cutting temperature is small. The impact of cutting speed on the cutting temperature is the most significant.