Variable lead thread though widely used, but its processing efficiency and quality has been a common problem, especially in variable width variable of lead screw machining of hard and difficult it is. Based on the variable lead helical thread on mathematical modeling, combined with FANUC computer numercial control (CNC) lathe of operating system specific examples, the macroprogram feature superior was used skillfully in turning quickly and accurately to complete the variable width variable lead screw. Finally complex variable lead thread is accomplished with highquality and highefficiency in getting twice the result with half the effort.