The fixture of robot based on vacuum adsorption was designed. Used in handling of lead ingot, the good effect was gotten. The structural composition of fixture based on vacuum adsorption was introduced. The working principle and technical characteristics of vacuum circuit and vacuum generator were described. The vacuum chuck, vacuum generator, solenoid valve and other major components were calculated and selected, and the fixture support was designed. It is analyzed using the finite element analysis (FEA) with Solidworks.