Based on the analysis of the technical requirements of automotive wheel hub manufacturing line, a kind of six degrees of freedom (6DOF) hydraulic handling robot of structure and control system was designed. The working principle of the hydraulic system was analyzed. In order to minimize the output of the hydraulic cylinder force, a mathematical model of output force of hydraulic cylinder and structural parameters were established, and the robot structure design was optimized based on Matlab software. Finally design calculation and analysis were done on the key components of hydraulic system. The analysis shows that the hydraulic system implements servo control on the robot, and satisfies handling requirements of automotive wheel hub, which research can be as reference for design of similar type of industrial robots’ hydraulic system. 