Industrial robots have been widely used in advanced manufacturing plants. Robot selection and simulation analysis is the key for robot application. Based on the requirements of cutting process and feeding, automatic fixture and special clamping jaw were designed. Based on FANUC ROBOGUIDE, the 3D model of machine tool, industrial robot, clamp, workpiece and material box were imported and combined. Feeding simulation was implemented by teaching programming. The results of simulation analysis verified the reasonability of robot selection. The layout of the whole system was adjusted to be more appropriated through the analysis of movement locus of robot.