The application of machine vision can greatly improve the accuracy and flexible of automation equipment, and enhance the Intelligence. The control system of automatic laminator was designed based on machine vision. After the pasting manipulator absorbed the membrane from export, the image was rapidly processed by the visual system, and the position data were sent to programmable logical controller (PLC), using C language function modules in the PLC, error compensation was processed, and the manipulator was controlled to complete the lamination process. In this way, it could effectively control precision, improve the efficiency of the machine, and greatly save the manpower cost. Through the test onsite, the laminator machine of work stability, accuracy and speed satisfy the predetermined needs.