A series of six degree of freedom (6-DOF) motion platform is designed. According to the characteristics of the platform，the mechanical subsystem model is built in the ADAMS dynamic analysis software. The hydraulic subsystem and the motor + ball screw drive model were built in the AMESim simulation software, and the desired position and attitude signal generation and decoupling control algorithm model were built in the Simulink simulation software for the end control object. By analysis of the data transmission characteristics between simulation softwares, a shared channel for dynamic data carrier was established by MATLAB software. The AMESim and ADAMS models were introduced to Simulink in the form of sub models and S functions.Thereby, the 6-DOF virtual test platform of the mechanical-electrical-hydraulic integration simulation system based on Simulink was established, and the simulation analysis of the platform was realized as a whole, to lay the foundation for the platform design and optimization, control strategy selection and so on. Using MATLAB-based simulation software ADAMS, AMESim, Simulink joint virtual test system to create methods for simulation of complex mechanical-electrical-fluid integration of systems of simulation analysis have general applicability.