The fracturing operation of fracturing ship is an important measure to improve the production of marine oil field. The fast separation device,which is designed to connect the manifold of fracturing ship and the manifold of offshore platform, plays a crucial role in emergency protection of marine fracturing operation. At present, international study on design and simulation analysis of the fast separation device control system in the process of fracturing operation is still a blank field. In the light of the above research situation,the hydraulic control system of fast separation device applied to the fracturing ship was designed on the basis of the operational principle of fracturing ship. Hydraulic system model of the fast separation device was built in AMESim hydraulic simulation software and the simulation analyses of main oil way at normal condition and fault condition were completed. The results show that the fast separation device can finish fast separation in 6 s with the process of high accuracy and good stability.