In view of the influence of inflow pulsation on the wall resistance of the pipeline, the influence of different inflow pulsation frequency on the wall resistance of the pipeline was analyzed by direct numerical simulation.The results show that the resistance on the pipe wall will change in the case of inflow pulsation;low frequency pulsation is conducive to the reduction of wall resistance;the closer the wall is,the greater the resistance reduction rate is;when the pulsation frequency is higher than 30 Hz, the wall resistance will increase;different pulse frequency and different distance to wall lead to different resistance rate. The results provide a theoretical reference for improving the transfer efficiency and energy utilization of the pipeline.