Sewage treatment in manufactory is a complex process with a high degree of uncertainty. In order to overcome the difficulty that it actualizes the precise control by mathematical modeling method, the present paper explored the intelligent fusion control strategy of sewage aeration process. In this paper, the control index of sewage pollution and the selection principle of control parameters were systematically analyzed, and the cybernetics of aeration process and the process control strategy were discussed. Based on intelligent agent control, the intelligent fusion strategy was studied and the control algorithm corresponding to the aeration process was designed as well. As compared with the experimental results, the simulation response demonstrated that the intelligent fusion control strategy has good control performance in terms of control precision, regulating and response time of process control, etc. Research results show that it is desirable and available to control the process of sewage aeration by using intelligent fusion strategy.