The service life of the spool will reduce greatly as the vibration of the multivalve valve spool. Therefore, the multiway valve spool was used as the research object, established the mathematical model of spool vibration response which combined with the principle of cavitation and vibration theory. ICEM was used to divide the spool, and the excitation response of the spool was calculated by introducing ANSYS under the boundary condition of the excitation force of 0.48 N. Finally, the vibration response map of the spool was obtained by the experimental study. Compared with the simulation results, it could be seen that the tangential vibration response of the spool under cavitation was higher than that of axial vibration. Due to the influence of the nonlinear vibration response during the experiment, the error of the vibration response amplitude is generated, which need to consider all aspects of the impact of factors，after the followup spool vibration indepth study.