The idea of honeycomb support structure performance optimization of horizontal machining center bed was proposed, and lathe bed was the original support structure changed into a honeycomb structure, and the performance index of the original structure and parallel comparison, analysis of the optimization effect. By using the parametric modeling method, analysis of honeycomb structure of unit cell parameters, density and frequency of the bed, the quality of the static deformation, equivalent stress relationship, the effect of honeycomb structure on the bed could be obtained. The improved design reference model using response surface method, analysis of the calculation results with the gray correlation method, and uses the improved entropy and gray correlation method, a comprehensive optimization evaluation standard for bed was made. In a machine tool factory in northwest of China, the production of type horizontal machining center as an example of optimization, parametric designed by ANSYS Workbench by selecting sides of cellular texture and thickness of rib board as design variables, the best optimization scheme of data processing and the gray correlation method with MATLAB software were analyzed and selected. The results show that the performance indexes of optimized machine tool has been greatly improved. The firstorder natural frequency is increased by about 24.1%, the bed mass is reduced by about 7.4%, the static deformation is reduced by about 26%, and the equivalent stress is reduced by about 35.1%