A certain amount of deformation occurs in the blind hole drilling process of aerospace panels due to the effect of fixture clamping.In order to obtain and display the hole drilling position data of deformed panels in real time and drive the manipulator to reach the exact hole drilling position,based on the idea of “combining the virtual with the real,and controlling the real by the virtual”,a real-time monitoring system for the hole drilling position of the aerospace panel based on the digital twin was proposed.The structure model of the 5-DOF manipulators hole drilling state monitoring system based on digital twin was built,and the structure of the system was described.The key technologies of digital twin system framework were analyzed respectively.Finally,the reliability of the digital twin hole drilling system was verified by taking the actual 5-DOF manipulator hole drilling as an example.The results show that the digital twin hole drilling system has good stability and effectiveness.