With the rapid development of information technology industry, information encryption is an effective means of information security. Data encryption system based on FPGA in the field of industry network is elaborated in this paper, and the data acquisition module, the basic principle of 3DES, the implementation in FPGA and PMC bus interface module are introduced. Based on the function simulation, test and analysis of the design results, this scheme shows the characteristics of high reliability, fast algorithm and less hardware resources, and it could be widely used in industrial networks.