At present, the types of products are complicated and the production batch is small, which makes the average waiting time for the workpiece in the production line too long, many in work and low in resource sharing. It is urgent to study the production mode of this type of problem. Taking a production line as an example,SIMIO software was used to make modeling and simulation optimization,two production modes of production lines and segmentation units were compared and analyzed.On this basis, a binary sorting algorithm was proposed for unit division, and the various types of production lines were analyzed and improved in the same environment. The results show that the unit production method based on binary sorting algorithm has superior performance in the aspects of equipment utilization, the average waiting time of the work piece, the number of work in work and so on.